So many questions....

We attempt to base our everyday clinical decisions on good evidence.  However, there continues to be large gaps in our knowledge base.  Which antipsychotic depot is the most effective?  Do community treatment orders prevent long readmissions?  It therefore warms the cockles of my heart when I see an answer to an important clinical question:  how do we best treat psychotic depression?  A recent meta-analysis supports the use of antidepressant-antipsychotic combination treatment, rather than monotherapy, for the acute management of psychotic depression.  No data yet on relapse prevention though.  

Reference: Farahan, A., Correll, U.  (2012)   Are Antipsychotics or Antidepressants Needed for Psychotic Depression? A Systematic Review and Meta-Analysis of Trials Comparing Antidepressant or Antipsychotic Monotherapy With Combination Treatment.  The Journal of Clinical Psychiatry vol 73, no. 4.”
Posted by Dr Jon Van Niekerk
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